Innovative Drug Research and Development
Based on the clinical demand of major diseases, the facility integrates pharmaceutical and clinical resources to establish a perfect drug research system (including pharmacology, drug design and synthesis, pharmaceutical preparations, drug quality control, drug metabolism, drug toxicology and other sub-platforms) to promote innovative drug target discovery and verification, clinical pharmaceutical research, and clinical trials ,etc. and to create a high level global innovation center for drug R&D.
(1) Innovative drug target discovery: combined with artificial intelligence and based on multiple omics databases and clinical bio-sample banks, conducting in-depth exploration of innovative drug targets through systemic biology (cell biology, molecular biology, animal modelling and pharmacology, etc.) studies.
(2) Design and synthesis of innovative drugs: analyzing the structure-activity relationship of compounds by artificial intelligence, rationally designing new compounds, constructing compound entity libraries, and accurately designing and synthesizing innovative drug candidates.
(3) Pharmaceutical preparations: developing typical preparation products for the characteristics of the quality control process to address the issues of poor solubility, stability and bioavailability, etc, developing sustained release, controlled release, targeting and other innovative preparations of drugs according to the clinical demands.
(4) Clinical pharmaceutical and clinical trial research: based on clinical drug resistance and adverse effects, screening clinical efficacy/toxicity markers through studies of pharmacology, drug metabolism and drug toxicology, designing new clinical drug treatment regimens, formulating clinical trial protocols and carrying out clinical trials of innovative drugs.
(5) Innovative drug research compliant with international declarations: conducting one-stop studies on pharmacology (API, preparation and quality control), pharmacodynamics, pharmacokinetics and safety evaluation according to the drug review and declaration requirements of China NMPA, US FDA and EU OECD.
Main equipments: HPLC, GC, LC-MS-MS instrument, GC-MS instrument, ICP-MS, Bruker NMR, drug design, molecular simulation and theoretical calculation computer clusters, blade-type high performance computer clusters, high content high-resolution living cell workstation, protein purification system, molecular interaction analysis system, automatic pipetting workstation, sorting flow cytometer, protein nucleic acid analyzer, fermentation tank, telemetry system for physiological signals of conscious animals, automatic blood cell analyzer, automatic micro blood biochemical analyzer, automatic vacuum freeze dryer for drugs, pilot soft capsule machine, fluidized granulating coating machine, hot melt extrusion granulator, etc.